Berberine Supreme™ | 500mg Berberine HCl + Bitter Melon & Banaba Leaf | Daily Defense®

Berberine Supreme™ — 500 mg Berberine HCl + Bitter Melon 10:1 + Banaba Leaf 1% Extract

Berberine is one of the most extensively researched plant alkaloids in modern nutritional science, with hundreds of published clinical studies examining its role in supporting healthy blood sugar metabolism, cardiovascular wellness, gut health, and metabolic function.* Daily Defense® Berberine Supreme™ delivers 500 mg of Berberine HCl per capsule alongside two complementary botanicals — Bitter Melon Fruit 10:1 Extract and Banaba Leaf 1% Extract — for a synergistic metabolic wellness formula.* Formulated in the USA. 60 vegetable capsules per bottle, 60-day supply.

What’s Inside (Per Capsule)

• Berberine HCl — 500 mg — Berberine is a quaternary ammonium alkaloid found naturally in plants such as barberry (Berberis vulgaris), goldenseal, and Oregon grape. Berberine HCl is the most studied and bioavailable salt form of berberine. It has been extensively studied for its role in supporting healthy blood glucose metabolism, healthy lipid levels, gut microbiome balance, and metabolic function via activation of AMP-activated protein kinase (AMPK) — a key cellular energy-sensing enzyme.*
• Bitter Melon Fruit 10:1 Extract — 100 mg — A concentrated 10:1 extract of Bitter Melon (Momordica charantia), equivalent to approximately 1,000 mg of whole bitter melon fruit. Bitter melon contains charantin, polypeptide-p, and vicine — bioactive compounds studied for their role in supporting healthy blood glucose metabolism and insulin sensitivity.*
• Banaba Leaf 1% Extract (Lagerstroemia speciosa) — 25 mg — Standardized to 1% corosolic acid, the primary bioactive compound in Banaba leaf. Corosolic acid has been studied for its role in supporting healthy glucose transport into cells and healthy blood sugar levels.*

Delivered in a plant-based vegetable cellulose (HPMC) capsule. Daily Value not established for any ingredient.

What It Supports

• Healthy blood sugar metabolism via Berberine HCl AMPK activation, Bitter Melon, and Banaba Leaf corosolic acid*
• Healthy insulin sensitivity and glucose transport via Bitter Melon and Banaba Leaf*
• Healthy lipid metabolism and cardiovascular wellness via Berberine*
• Gut microbiome balance and digestive wellness via Berberine*
• Metabolic function and energy metabolism support via AMPK activation*

Who Is This For?

Daily Defense® Berberine Supreme™ is designed for adults looking to support healthy blood sugar metabolism, metabolic function, and cardiovascular wellness with a clinically studied botanical formula. It may be a good fit if you:

• Want 500 mg of Berberine HCl — the most studied and bioavailable form of berberine — per capsule
• Are looking for a formula that combines Berberine with Bitter Melon 10:1 and Banaba Leaf (1% corosolic acid) for synergistic metabolic support*
• Want a fully plant-based vegetable capsule formula
• Want a 60-day supply in a single bottle at 1 capsule per day

How to Use

Take 1 vegetable capsule 1 to 2 times daily, preferably with meals, or as directed by a healthcare professional. Each bottle contains 60 vegetable capsules.

Quality You Can Trust

Daily Defense® is committed to delivering supplements that meet the highest standards of quality and purity. Berberine Supreme™ is formulated in the USA, produced in a GMP-certified facility, and third-party tested to help ensure the quality and integrity of every bottle.